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Somatic Mosaicism in the Human Genome - ncbim.nih.gov · 1.1. Early Studies of Mosaicism. Somatic mosaic mutations are defined as mutations that occur in some cells of the soma of a single individual (Figure 1) [1,2].The mixture of mutation-positive cells with non-mutated cells results in an individual who is a mosaic, or contains different DNA within different cells of his or her body.